4/8/2023 0 Comments Argyria colloidal silver blueThe corrosive effects are likely to be due to the nitrate in the compound rather than by the silver itself. ,, Instillation of silver nitrate in the renal pelvis or urinary tract for chyluria have been reported to be associated with renal and hepatic failure, acute necrotizing ureteritis, obstructive nephropathy and papillary necrosis. The acute toxicity due to exposure to large doses of inorganic silver salts such as silver nitrate is similar to corrosive effects leading to irritation of the gastrointestinal tract (if ingested) manifested in the form of epigastric burning, vomiting and diarrhea or respiratory tract irritation (if inhaled), severe toxicity will cause decreased blood pressure and decreased respiration ultimately leading to convulsions and shock. , The metallic and inorganic silver compounds ionize to silver ion on exposure to body fluids, which after absorption in the systemic circulation by ion uptake binds to thiol and proteins ligands such as metallothioneins, albumins and macroglobulins and is metabolized. , The percutaneous absorption through intact skin is very low, however, in wounds and burns the absorption increases significantly. Silver is absorbed into the body through inhalation, ingestion, intraparentaral through insertion of needles or implantation of medical devices or accidental puncture wounds and through dermal or mucosal contact. , Absorption of metallic silver is much less when compared with soluble silver compounds. The ability of a metal to produce toxic effects on body depends on the type of compound/form of the metal, the amount and mode of absorption, its metabolism in the body and the cellular vulnerability to toxic damage. Normal healthy people have silver levels of <3 μg/L. It is present widely in the human environment henceforth, low concentrations are also present in the human body. Silver is a naturally occurring metallic element that has no known physiological or biological function in the human body.
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